Which of the following is true about Schedule I drugs?

• A. They are safe for over-the-counter sale.
• B. They have low abuse potential.
• C. They have medical use in some contexts.
• D. They have no currently accepted medical use and a high potential for abuse.

Answer: (D)

Schedule I drugs are defined by having no currently accepted medical use in the United States and a high potential for abuse. This combination makes them the most restricted class: they are not legally prescribed, not sold over the counter, and they carry the greatest concerns about dependence and harm. Examples include heroin and LSD. Because there’s no approved medical use under current law, these substances face strict regulatory barriers for research and cannot be used medically in practice. The other statements contradict this definition: they are not safe for OTC sale, they do not have low abuse potential, and they do not have medical use in any context.